Session Chair: Þór Eysteinsson
14:45-15:00: Absence of Mitf leads to neurodegeneration in aging mice
15:00-15:15: Promoting remyelination with AMPAkines
15:15-15:30: Many genes contribute to temperature regulation in mammals
15:30-15:45: A novel mouse and neuronal model to mechanistically test hypothesis in Kabuki syndrome
Abstracts in session A-Z
A novel mouse and neuronal model to mechanistically test hypothesis in Kabuki syndrome
Hilmar Örn Gunnlaugsson. Kabuki syndrome (KS) is a rare Mendelian disorder of the epigenetic machinery. We have shown phenotypic similarities with patients and other KS mouse models in a novel patient specific mouse model. This provides us with novel means to uncover mechanistic insights for KS.
Absence of Mitf leads to neurodegeneration in aging mice
Fatich Mechmet. Primary neurons from the olfactory bulb of young Mitf null mice are hyperactive indicating the possible role of MITF protein in homeostatic intrinsic plasticity. Aging Mitf null mice lose olfactory ability, possibly due to alterations in neuronal activity.
Many genes contribute to temperature regulation in mammals
Aðalhöfundur: Salvör Rafnsdóttir
Kjarnhitastig ENU unga var skimað fyrir afbrigðileika í hitastigsstjórnun með og án kæliáreitis. Niðurstöður benda til að nokkrir sameiginlegir stórir ferlar taka þátt í hitastigsstjórnun þ.s. jákvæðar svipgerðir skiptast í flokka þ.e. breytingar á grunnhitastigi, hitastigútslögum og dægursveiflu
Promoting remyelination with AMPAkines
Aðalhöfundur: Sif Ólafsdóttir. MS is an autoimmune disease characterised by myelin damage. No myelin regenerative treatments exist. We are now investigating if increasing the axon-OPC communication via AMPA receptor agonists can improve myelin repair.