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GESTA MÁLSTOFA

Líf - og heilbrigðisvísindaráðstefna Háskóla Íslands 2021

Neuroscience in Iceland

Flytjendur:

Tími, upplýsingar um málstofu

Session Chair: Þór Eysteinsson

14:45-15:00: Absence of Mitf leads to neurodegeneration in aging mice
15:00-15:15: Promoting remyelination with AMPAkines
15:15-15:30: Many genes contribute to temperature regulation in mammals
15:30-15:45: A novel mouse and neuronal model to mechanistically test hypothesis in Kabuki syndrome

Abstracts in session A-Z

A novel mouse and neuronal model to mechanistically test hypothesis in Kabuki syndrome

Hilmar Örn Gunnlaugsson. Kabuki syndrome (KS) is a rare Mendelian disorder of the epigenetic machinery. We have shown phenotypic similarities with patients and other KS mouse models in a novel patient specific mouse model. This provides us with novel means to uncover mechanistic insights for KS.

LESA ÁGRIP

Absence of Mitf leads to neurodegeneration in aging mice

Fatich Mechmet. Primary neurons from the olfactory bulb of young Mitf null mice are hyperactive indicating the possible role of MITF protein in homeostatic intrinsic plasticity. Aging Mitf null mice lose olfactory ability, possibly due to alterations in neuronal activity.

LESA ÁGRIP

Many genes contribute to temperature regulation in mammals

Aðalhöfundur: Salvör Rafnsdóttir
Kjarnhitastig ENU unga var skimað fyrir afbrigðileika í hitastigsstjórnun með og án kæliáreitis. Niðurstöður benda til að nokkrir sameiginlegir stórir ferlar taka þátt í hitastigsstjórnun þ.s. jákvæðar svipgerðir skiptast í flokka þ.e. breytingar á grunnhitastigi, hitastigútslögum og dægursveiflu

LESA ÁGRIP

Promoting remyelination with AMPAkines

Aðalhöfundur: Sif Ólafsdóttir. MS is an autoimmune disease characterised by myelin damage. No myelin regenerative treatments exist. We are now investigating if increasing the axon-OPC communication via AMPA receptor agonists can improve myelin repair.

LESA ÁGRIP

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