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PRESENTED IN ENGLISH

Biomedical and Health Sciences Conference at the University of Iceland

Molecular Biology II

Presenters:

Time, type of presentation:

Session Chair: Jón Jóhannes Jónsson

14:20-14:35: Mapping interactions of the maedi-visna virus Vif protein with cellular factors
14:35-14:50: Molecular regulators of catecholamine response in human pulmonary microvascular endothelial cells
14:50-15:05: Role of MITF during melanocyte development as determined by a conditional mutation
15:05-15:20: Elucidating the mechanism of chromatin remodelling by the pioneer transcription factor Sox2

Abstracts in session A-Z

Elucidating the mechanism of chromatin remodelling by the pioneer transcription factor Sox2

Main Author: Sveinn Bjarnason. Sox2 is a pioneer transcription factor that can target condensed nucleosome rich chromatin. Using smFRET, we observed that Sox2 can bind to both free and H1-bound nucleosomes, with a specific role for the intrinsically disordered regions in DNA binding.

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Mapping interactions of the maedi-visna virus Vif protein with cellular factors

Aðalhöfundur: Stefán Ragnar Jónsson. Spendýr verjast retróveirum með APOBEC3(A3) próteinum sem valda stökkbreytingum sem afvirkja veiruna. Svar lentiveira er próteinið Vif sem sendir A3 til eyðingar í niðurbrotskerfi frumunnar. Í þessu verkefni voru bindisvæði mæði-visnuveiru Vif við prótein sem taka þátt í niðurbroti A3 skoðuð.

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Molecular regulators of catecholamine response in human pulmonary microvascular endothelial cells

Adrian Lopez Garcia de Lomana. Molecular regulators of catecholamine response in human pulmonary microvascular endothelial cells.

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Role of MITF during melanocyte development as determined by a conditional mutation

Main author : Romain Lasseur. We have generated a mouse model inducing a conditional and hypomorphic MITF mutation in order to be able to study the fate of melanoblasts. Thus, our work will give us a better understand of the role of MITF in melanocytes during their development.

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