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PRESENTED IN ENGLISH

Biomedical and Health Sciences Conference at the University of Iceland

Immunology

Presenters:

Time, type of presentation:

Session Chair: Helga Ögmundsdóttir

09:15-09:30: Diminished early regulatory differentiation by the adjuvant LT-K63 promotes B-cell germinal center commitment through enhanced-IL-21R-expression
09:30-09:45: LT-K63 enhances B-cell activation and survival factors in neonatal mice translating into long-lived humoral immunity
09:45-10:00: Short Vi-polysaccharide conjugate abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM197 conjugate vaccine
10:00-10:15: Dietary fish oil induces recruitment of differentiated NK cells and enhances resolution of antigen-induced peritonitis
10:15-10:30: Detailed multiplex analysis of SARS-CoV-2 specific antibodies in COVID-19 disease

Abstracts in session A-Z

Detailed multiplex analysis of SARS-CoV-2 specific antibodies in COVID-19 disease

Main author: Hildur Sigurgrímsdóttir Institution or Company: Landspítali og Læknadeild Háskóla Íslands Co-Authors, Institution or Company: Siggeir F. Brynjólfsson, Landspítali og Læknadeild Háskóla Íslands, Elín D. Einarsdóttir, Læknadeild Háskóla Íslands2, Guðrún A. Björnsdóttir, Landspítali og Læknadeild Háskóla Íslands, Brynja Armannsdóttir, Landspítali,  Guðrún E. Baldvinsdóttir, Landspítali, Agnar Bjarnason,Landspítali og Læknadeild Háskóla Íslands, Ólafur Guðlaugsson. Landspítali, Sveinn …

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Dietary fish oil induces recruitment of differentiated NK cells and enhances resolution of antigen-induced peritonitis

Main author: Kirstine Nolling Jensen
In this study we further characterized the effects of fish oil on NK cells and resolution of inflammation and saw increased recruitment of differentiated NK cells, possibly through CCL5 and CXCL12, and increased soluble TNFRII, possibly neutralizing TNF.

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Diminished early regulatory differentiation by the adjuvant LT-K63 promotes B-cell germinal center commitment through enhanced-IL-21R-expression

Stefanía P Bjarnarson et al. demonstrate that one of the major mechanistic properties of LT-K63 is its ability to circumvent early preferential induction of suppressive regulatory cells during early life, thereby allowing better induction of effector cells that contribute to enhanced and prolonged immune responses to vaccines.

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LT-K63 enhances B-cell activation and survival factors in neonatal mice translating into long-lived humoral immunity

Main author: Auður Anna Aradóttir Pind. In this study the authors sought to pinpoint which molecular pathways the adjuvant LT-K63 activated that could contribute to enhanced and sustained humoral immunity in the young, using a neonatal mouse model.

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Short Vi-polysaccharide conjugate abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM197 conjugate vaccine

The authors Stefania P Bjarnarson and Francesca Micoli share equal contribution as co-first authors, and Ingileif Jónsdóttir and Allan Saul share equal contribution as co-last authors. Our results suggest a rational way of designing and developing an improved typhoid conjugate vaccine and to conjugate vaccines in general.

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