Flokkur: Krabbamein

MiR-21-3p influences breast cancer progression

Arsalan Amirfallah: We analyzed if miR-21-3p expression can predict patient prognosis. Our results indicate that high miR-21-3p expression is associated with a worse prognosis for breast cancer patients and it affects pathways that support breast tumor proliferation.

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Epitranscriptomic regulation of DNA repair genes

Main author: Karen Kristjánsdóttir
Project focuses on a key protein in the DNA-DSB repair pathway, RNF168 and how it is regulated by two members of the AlkB-family of alkylation damage repair proteins, ALKBH3 and FTO. They do so by removing a methylation mark from the RNF168 mRNA transcript.

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BRCA2 haploinsufficiency in telomere maintenance

Sigríður K. Böðvarsdóttir lýsir arfstökum áhrifum arfgengra BRCA2 stökkbreytinga á telomere galla í eitilfrumulínum. Telomere gallar greindir með FISH aðferð reyndust stigmagnast í eitilfrumulínum með arfblendnar og arfhreinar BRCA2 stökkbreytingar samanborið við villigerð. Telomere gallar geta aukið krabbameinsáhættu arfbera.

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