Main author: Sigurður Rúnar Guðmundsson
Company or Institution: University of Iceland, University of Helsinki
Co-Authors, Institution or Company:
Shun Kageyama, Juntendo University. Eeva-Liisa Eskelinen, University of Turku. Masaaki Komatsu, Juntendo University.
Introduction: Selective autophagy plays an important role in the degradation of lipid droplets such as P-Granule, Ape1 Complex and p62/SQSTM1 bodies. In a recent paper we described the properties endogenous P62-bodies, the role of autophagy in their degradation and the significance of their turnover in vivo.
Methods: P62-bodies are low -liquidity gels containing ubiquitin and autophagy core proteins. We observed multiple autophagosomes forming on the p62-gels. Keap1 translocate to the p62-gels and activates the transcription factor Nrf2. Atg7 deficient mice had impaired p62-gel turnover which leads to Nrf2 hyperactivation in vivo.
Results: Our results indicate that p62-gels are not only substrates for autophagy but also a platform for autophagosome formation and play a role in anti-oxidative stress.
